Observational studyHernia : the journal of hernias and abdominal wall surgery2026
Gut microbiota characteristics in patients with inguinal hernia: a prospective observational study.
Observational study in Hernia : the journal of hernias and abdominal wall surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeGut microbiota plays a critical role in regulating muscle function via the gut-muscle axis. However, the association between the gut microbiota and inguinal hernia remains largely unexplored. This study aims to characterize the gut microbiota composition in a cohort of inguinal hernia patients.
methods68 inguinal hernia patients and 50 control subjects were recruited. Bacterial 16 S rRNA gene sequencing was applied to profile the gut microbiota composition in feces. LEfSe method was used to analyze the enriched bacterial taxa. Microbiota functional profiling was conducted using the PICRUSt.
results52 patients were diagnosed with indirect hernia, and 16 individuals suffered from direct hernia. The beta diversity showed significant difference in amplicon sequence variants (ASV)-level clustering between hernia patients and control subjects. The relative abundance of the phylum Bacillota was increased, whereas the phyla Pseudomonadota, Actinobacteria, and Bacteroidota were decreased in the hernia patients. The inguinal hernia patients exhibited higher abundances of genera Blautia, Ruminococcus, Anaerobutyricum, and Dorea, while lower abundances of genera Phocaeicola, Enterobacter, Delftia, and Alistipes than the control subjects. The direct hernia group showed higher relative abundances of genera Enterococcus and Segatella than the indirect hernia group. LEfSe feature selection revealed several genera and species that discriminated the inguinal hernia and control subjects. Furthermore, microbiota functional profiling showed perturbed KEGG and COG pathways in the hernia patients.
conclusionInguinal hernia patients present a distinct gut microbial profile marked by reduced beta diversity and altered taxonomic composition, with specific bacterial taxa differentiating indirect, direct inguinal hernia and control subjects.
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