ArticlePediatric surgery international2026
Relative frequency of non-Wilms renal tumours in children: an institutional experience from a national tertiary referral centre in Malaysia.
Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeInternational protocols for paediatric renal tumours are largely based on Western data with Wilms tumour (WT) accounting for more than 90% of cases. We aimed to evaluate the relative frequency of WT and Non-Wilms Renal Tumours (NWRTs) in a diverse Asian cohort in Malaysia.
methodsA retrospective review was conducted of all primary paediatric renal tumours treated at a national tertiary referral centre from 2015 to 2024. Diagnosis was confirmed via post-operative histopathology.
resultsOf 95 children (median age 29 months), all were Asian descent (73.7% Malay, 9.5% Chinese, 6.3% Indian). WT accounted for only 68.4% of cases, while NWRTs accounted for 31.6%. Among NWRTs, 63.3% were malignant, primarily clear cell sarcoma of the kidney (CCSK, n = 7) and renal cell carcinoma (RCC, n = 4). In the classic WT age range (6-84 months), WT prevalence was only 75.6%, with CCSK representing 9.0%. Congenital mesoblastic nephroma (CMN) predominated in infants < 6 months (71.4%), while RCC was exclusively seen in children > 84 months (40.0%).
conclusionThe substantial proportion of malignant NWRTs observed in this institutional cohort highlights potential risks of neoadjuvant chemotherapy without histological confirmation. Histopathological diagnosis via percutaneous core-needle biopsy or primary surgery may be highly considered in similar clinical settings.
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