Response surface-optimized Cycas revoluta leaf extract attenuates experimental ulcerative colitis through anti-inflammatory and oxidative stress-related mechanisms.

Asmaa M Akar, Samar A El-Adawy, Nesrine M Hegazi, Ahmed Zayed, Souzan M Ibrahim

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Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Asmaa M AkarDepartment of Pharmacognosy, College of Pharmacy, Gharbia Governorate, Tanta University, El-Guish Street (Medical Campus), Tanta, 31527, Egypt.

Samar A El-AdawyDepartment of Biochemistry, College of Pharmacy, El-Guish Street (Medical Campus), Tanta University, Tanta, 31527, Egypt.

Nesrine M HegaziDepartment of Phytochemistry and Plant Systematics, Institute of Pharmaceutical Industries, National Research Centre, Dokki, 12622, Cairo, Egypt.

Ahmed ZayedDepartment of Pharmacognosy, College of Pharmacy, Gharbia Governorate, Tanta University, El-Guish Street (Medical Campus), Tanta, 31527, Egypt. ahmed.zayed1@pharm.tanta.edu.eg.ORCID https://orcid.org/0000-0001-5747-6972

Souzan M IbrahimDepartment of Pharmacognosy, College of Pharmacy, Gharbia Governorate, Tanta University, El-Guish Street (Medical Campus), Tanta, 31527, Egypt.

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6 · The paper itself

Abstract

Cycas revoluta Thunb. has traditionally been used for the management of gastrointestinal and inflammatory disorders, but its bioactive constituents and anti-inflammatory potential remain insufficiently characterized. This study aimed to optimize the extraction of phenolic-rich compounds from C. revoluta leaves and evaluate the anti-inflammatory and coloprotective effects of the optimized extract against experimental ulcerative colitis (UC). Four extraction techniques, namely Soxhlet extraction, maceration, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE), were compared based on extraction yield, total phenolic content (TPC), total flavonoid content (TFC), antioxidant, and antibacterial activities. The most effective method was subsequently optimized using response surface methodology (RSM) using a Box-Behnken design (BBD), followed by phytochemical investigation and biological evaluation in rats with acetic acid-induced UC. Maceration showed the best performance, yielding the highest TPC (44.21 mg GAE g

Indexed as

Anti-inflammatory activityBiflavonoidsColoprotective effectCycas revoluta Thunb.Response surface methodologyUlcerative colitis

Identifiers

PMID42905295

DOI10.1186/s13020-018-0177-x

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