ArticleCell and tissue research2026
Serum and uterine fluid extracellular vesicles and prostaglandin E metabolite concentrations during diestrus and early pregnancy in mares.
Article in Cell and tissue research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Prostaglandins produced by endometrial and conceptus tissues have an established role in maintaining luteal function in early pregnancy and initiating luteolysis during diestrus in mares. The cellular mechanisms controlling the secretion and delivery of prostaglandins have not been fully elucidated. We hypothesized that nanosized lipid bilayer extracellular vesicles (EV) that carry a variety of biological molecules would be involved in these key regulatory processes. Serum and uterine fluid samples were collected from diestrus and pregnant mares on day (D) 10 and D14 post-ovulation, and conceptuses were collected in pregnant mare cycles and cultured for 2-3 h. Extracellular vesicles were isolated using membrane affinity spin columns. Metabolomic EV cargo was assessed using LC-MS/MS, and cytosolic phospholipase A2 (cPLA2) with immunoblotting. Serum and uterine fluid PGEM and conceptus PGE
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