ArticleInternational urogynecology journal2026
Cumulative Incidence and Surgical Risk Factors for Severe Postoperative Complications in the Treatment of Primary Uterovaginal Prolapse: A Systematic Review and Meta-Analysis.
Article in International urogynecology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisApical repairs for uterovaginal prolapse (UPOP) are generally elective procedures with significant quality-of-life benefit; however, uncommon and potentially severe complications may occur. Our goal was to perform a systematic review and meta-analysis to understand risks for and estimate the incidence of major complications of common surgical approaches to UPOP repair.
methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched MEDLINE and EMBASE through 11/11/25 for studies describing risk factors for, or incidence of, severe complications due to surgical UPOP repair. Data collected included risk factor analysis and incidence data for major intraoperative injury (bowel, bladder, ureteral, or nerve) and major surgical complications (transfusion, small bowel obstruction, perioperative death, mesh complication, reoperations, and readmissions, and sum of any major complication). Pooled proportions were estimated using a random-effects meta-analysis of proportions, and between-group comparisons were performed using mixed-effects meta-regression for major surgical approaches to UPOP repair (vaginal native tissue (VNT), minimally invasive sacrocolpopexy (MIS SCP), transvaginal mesh (TVM); all transabdominal MIS (laparoscopic/robotic), all vaginal reconstructive; VNT with hysterectomy, and VNT with hysteropexy).
resultsOf the 8890 abstracts screened, 46 studies met the inclusion criteria. Overall quality of evidence was moderate. MIS had higher pooled incidence of intraoperative bowel injury compared to vaginal approaches (0.48%; CI 0.27-0.84 vs 0.18%; CI 0.09-0.35, p = 0.028); however, with lower risk of transfusion (0.35%; CI 0.14%-0.87% vs 0.99%; CI 0.67%-1.46%, p = 0.04). Total intraoperative injury estimates were similar between groups (0.11%; CI 0.01-0.81 vs 0.65%; CI 0.20-2.06. p = 0.135). TVM was associated with higher total major complications (17.98%; CI 9.44-31.56) than VNT (5.01%; CI 3.07-8.07) or MIS SCP (6.41%; CI 4.13-9.84) p = 0.007. A narrative review of risk factors for surgical complications identified significant heterogeneity and low confidence in reported risk factors.
conclusionsSevere complications following repair of primary UPOP are infrequent. Abdominal MIS carry higher risk of bowel injury, with lower risk of transfusion compared to vaginal approaches. These data should inform shared decision-making for surgeons and patients considering surgical repair for primary UPOP.
Indexed as
Identifiers
42905161What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.