ArticleChemistry & biodiversity2026
Synthesis of 1,2,3-Triazole Derivatives of N,N-Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro.
Renato Pinto de Sousa, William Cezar de Lima Silva, Caíque Lopes Duarte, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Fernanda Alice de Oliveira, Fernando de Pilla Varotti, Bruno Antônio Marinho Sanchez, Mahendra Rai, Maurício Pires de Moura do Amaral and 4 more
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In one paragraphArticle in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
William Cezar de Lima SilvaDepartment of Chemistry, Federal University of Espírito Santo, Vitória, Brazil.
Caíque Lopes DuarteResearch Center in Biological Chemistry (NQBio), Federal University of São João Del-Rei, Divinópolis, Brazil.
Ana Claudia de Souza PintoResearch Center in Biological Chemistry (NQBio), Federal University of São João Del-Rei, Divinópolis, Brazil.
Amanda Luisa da FonsecaResearch Center in Biological Chemistry (NQBio), Federal University of São João Del-Rei, Divinópolis, Brazil.
Bruno Antônio Marinho SanchezImmunopathology and Tropical Diseases Laboratory, Federal Research and Educational Support Center in Health (NUPADS), Institute of Health Sciences, University of Mato Grosso, Sinop, Brazil.ORCID https://orcid.org/0000-0001-9097-0112 Mahendra RaiDepartment of Chemistry, Federal University of Piauí, Teresina, Brazil.
Mariana Helena ChavesDepartment of Chemistry, Federal University of Piauí, Teresina, Brazil.
João Sammy Nery de SouzaDepartment of Chemistry, Federal University of Piauí, Teresina, Brazil.
Funding
Aperfeiçoamento de Pessoal de Nível Superior - Brasil CAPES-SCBA88881.507222/2020-01Fundação de Amparo à Pesquisa do Estado de Mato Grosso FAPEMAT-018-2022Fundação de Amparo à Pesquisa do Estado de Minas Gerais Fapemig-APQ-01087-23Fundação de Amparo à Pesquisa do Piauí CT-INFRA007/2018Fundação de Amparo à Pesquisa e Inovação do Espírito Santo FAPES308/2022-PINCTBioNat 465637/2014-0National Council for Scientific and Technological Development 302386/2022-0National Council for Scientific and Technological Development 302565/2022-1National Council for Scientific and Technological Development 402302/2021-4National Council for Scientific and Technological Development CNPq 317894/2025-0National Institute of Science and Technology (INCT), through the INCT T-Bio2 - Translational Biodiscovery and Biomodels 408566/2024-8
6 · The paper itselfAbstract
Malaria is a severe parasitic disease, with Plasmodium falciparum as one of the main etiological agents. The growing resistance to antimalarial drugs underscores the urgent need for the development of new therapeutic agents. This study describes the semisynthesis of eight new 1,4-disubstituted 1,2,3-triazole derivatives (3-10) from N,N-dimethyltryptamine (1), isolated from Mimosa tenuiflora. The derivatives were obtained through copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reactions and characterized by NMR and mass spectrometry. Compound 1 showed low in vitro activity against the W2 strain of P. falciparum (IC
Indexed as
AntimalarialsMimosaPlasmodium falciparumTriazolesHumansMolecular Docking SimulationMolecular StructureParasitic Sensitivity TestsPlant BarkPlant RootsStructure-Activity RelationshipAntimalarialsTriazolesclick chemistryindole derivativesmolecular dockingparasite inhibition
Identifiers
PMID42904838
PMCPMC13685483
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