E2 Glycoprotein of BVDV 1u Circulating in Qinghai Yaks: A Candidate for Serological Surveillance and Subunit-Vaccine Development With Neutralizing-Antibody Evaluation in Yaks.

Jie Li, Ru Meng, Zhi Li, Yuan Han, Jinshu Sui, Shuai Wang, Shandian Gao, Yong Fu

Abstract read

In one paragraph

Article in Transboundary and emerging diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie LiAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.

Ru MengXining Animal Disease Prevention and Control Center, Xining, 810003, China.

Zhi LiAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.ORCID https://orcid.org/0000-0003-4694-662X

Yuan HanAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.ORCID https://orcid.org/0009-0002-5810-6732

Jinshu SuiAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.

Shuai WangAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.

Shandian GaoState Key Laboratory of Animal Disease Prevention and Control, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, China, caas.cn.ORCID https://orcid.org/0000-0003-3540-7882

Yong FuAcademy of Animal Science and Veterinary Medicine, Qinghai University, Xining, 810016, China, qhu.edu.cn.ORCID https://orcid.org/0000-0003-3354-9107

Funding

Key R & D and transformation plan of Qinghai Province 2024-NK-103

6 · The paper itself

Abstract

Bovine viral diarrhea (BVD) virus (BVDV) is a globally distributed Pestivirus that severely affects the cattle industry, and Pestivirus bovis (formerly BVDV-1), subgenotype 1u is the predominant subtype circulating in yak populations of Qinghai, China. This study aimed to express the N-terminal fragment (amino acids 1-200) of the E2 glycoprotein of yak-origin BVDV 1u and identify its antigenic and immunogenic properties for potential application in serological surveillance and subunit-vaccine development. Using the purified truncated E2 antigen, an indirect ELISA was established for detection of BVDV-specific antibodies from yak sera. Immunogenicity for the recombinant protein was evaluated in BALB/c mice using Freund's adjuvant and Montanide ISA 201 VG by determining CD4

Indexed as

Bovine Virus Diarrhea-Mucosal DiseaseDiarrhea Virus 1, Bovine ViralViral Envelope ProteinsViral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralCattleChinaEnzyme-Linked Immunosorbent AssayFemaleMiceMice, Inbred BALB CProtein Subunit VaccinesVaccine DevelopmentVaccines, SubunitAntibodies, NeutralizingAntibodies, Viralgp53, bovine viral diarrhea virusProtein Subunit VaccinesVaccines, SubunitViral Envelope ProteinsViral Vaccinesbovine viral diarrhea virus (BVDV)BVDV 1uE2 proteinimmunogenicityindirect ELISAneutralizing-antibody evaluationserosurveillancevaccine antigenyak

Identifiers

PMID42904801

DOI10.1155/tbed/3180012

PMCPMC13685502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.