Evidence map›Paper›PMID 42904532›Full record

ArticlePlant biotechnology journal2026

The Cytosolic Iron-Sulfur Cluster Assembly Targeting Complex Is Hijacked by Magnaporthe Effector AvrPi9 to Suppress Rice Resistance.

Huanbin Shi, Zhiquan Liu, Ying Zhang, Runjing Li, Zhizhen Fu, Ya Chen, Hui Wen, Liang Cai, Zhengting Chen, Jiehua Qiu and 1 more

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Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Huanbin ShiState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Zhiquan LiuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Ying ZhangState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Runjing LiState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Zhizhen FuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Ya ChenState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Hui WenState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Liang CaiState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Zhengting ChenState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Jiehua QiuState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.
Yanjun KouState Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, China.ORCID https://orcid.org/0000-0003-4189-0962

Funding

Agricultural Sciences and Technologies Innovation Program CAAS-CSCB-202301Central Public-interest Scientific Institution Basal Research FundIndependent Research Project of the State Key Laboratory of Rice Biology and Breeding 2026ZZKT21103National Natural Science Foundation of China 32171944National Natural Science Foundation of China 32441050National Natural Science Foundation of China 32470208Zhejiang Provincial Natural Science Foundation of China LR24C140001
6 · The paper itself

Abstract

The cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) targeting complex mediates the maturation of cytosolic and nuclear Fe-S proteins and governs core eukaryotic cellular processes. However, whether this complex contributes to plant disease resistance remains unclear. Here, we show that the Magnaporthe oryzae avirulence effector AvrPi9 targets the host CIA targeting complex to suppress rice blast resistance. AvrPi9 physically interacts with and stabilizes OsAE7, a core subunit of the CIA targeting complex. Using biochemical and genetic approaches, we demonstrate that OsAE7 facilitates Fe-S protein maturation, including the Fe-S protein aconitase OsACO1, and negatively regulates blast resistance in cooperation with another CIA targeting complex subunit, OsCIA1, and the carrier protein OsNAR1 in rice. Furthermore, ectopic expression of AvrPi9 enhances the activity of the CIA complex and the maturation of OsACO1. Knockout of OsACO1 elevates ferrous iron levels, triggers a reactive oxygen species (ROS) burst, and activates pathogenesis-related gene transcription, thereby strengthening rice resistance to blast. Our findings reveal a critical role of the CIA targeting complex in plant disease resistance and uncover a novel virulence strategy whereby AvrPi9 hijacks the host CIA pathway to dampen basal resistance and promote infection.

Indexed as

avirulence factorcytosolic iron–sulfur cluster assembly pathwaydisease resistanceiron homeostasisMagnaporthe oryzaeOryza sativarice blast

Identifiers

PMID42904532
PMCPMC13685401

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.