Evidence map›Paper›PMID 42904253›Full record

ArticleChemical science2026

Exploiting inosine as a distinctive cleavage site for deriving a highly specific RNA-cleaving DNAzyme.

Shusen Xiao, Pan Jia, Kai Niu, Xiaoqian Li, Xiaozheng Li, Yangyang Chang, Zijie Zhang, Hong Yuan, Jiuxing Li, Meng Liu

Abstract read
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shusen XiaoCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.
Pan JiaCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.
Kai NiuCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.
Xiaoqian LiSchool of Environmental Science and Technology, Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian University of Technology Dalian 116024 China.
Xiaozheng LiSchool of Environmental Science and Technology, Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), Dalian University of Technology Dalian 116024 China.
Yangyang ChangCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.
Zijie ZhangCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.ORCID https://orcid.org/0000-0003-2757-3071
Hong YuanCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.
Jiuxing LiCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.ORCID https://orcid.org/0000-0001-7012-2482
Meng LiuCentral Hospital of Dalian University of Technology, Dalian Medical-Engineering Interdisciplinary Rapid Diagnosis of Major Diseases Laboratory, Dalian University of Technology Dalian 116000 China yuanhonglab@163.com lijiuxing@dlut.edu.cn mliu@dlut.edu.cn.ORCID https://orcid.org/0000-0003-3114-9003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most RNA-cleaving DNAzymes are limited to cleaving between combinations of the four canonical ribonucleotides. Through

Identifiers

PMID42904253
PMCPMC13682592

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.