ReviewFrontiers in microbiology2026
Arbovirus diagnostics: from conventional methods to emerging technologies-a chikungunya virus-centric review.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
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Abstract
Arboviruses remain an important global health concern because of their expanding distribution, diverse transmission patterns, and the challenges associated with accurate and timely diagnosis. This review is centered on Chikungunya virus (CHIKV) as a representative model, focusing on diagnostic strategies across different stages of infection and the key diagnostic pitfalls that affect CHIKV detection in co-circulation settings. In this review, we summarize current laboratory-based approaches for CHIKV detection and differential diagnosis, including virus isolation, antigen detection, nucleic acid amplification and serological assays, with discussion of their applications, strengths and limitations. We further review recent developments in emerging diagnostic technologies, including next-generation sequencing, CRISPR-based detection methods, aptamer-based recognition systems, biosensors, and point-of-care testing platforms, highlighting their potential advantages and current limitations. Comparative examples involving dengue virus (DENV) and Zika virus (ZIKV) are discussed specifically to illustrate cross-reactivity and misclassification risks relevant to CHIKV diagnosis. Particular attention is given to persistent issues affecting diagnostic accuracy and practical implementation, including serological cross-reactivity among co-circulating arboviruses and the challenges of translating advanced technologies into accessible tools for field and resource-limited settings. Overall, this review summarizes progress in CHIKV-relevant diagnostics and outlines future opportunities for developing more reliable, rapid, and widely applicable detection strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.