Evidence map›Paper›PMID 42904217›Full record

ArticleRSC advances2026

Daturolides A-K, cytotoxic sesquiterpene lactones from

Ji-Yeon Hwang, Brice A P Wilson, Lindsay Marron, Shar-Yin Naomi Huang, Ekaterina I Goncharova, Dongdong Wang, Yves Pommier, Barry R O'Keefe, Lin Du

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ji-Yeon HwangMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.ORCID https://orcid.org/0009-0005-0157-5724
Brice A P WilsonMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.ORCID https://orcid.org/0000-0001-8988-1964
Lindsay MarronMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.
Shar-Yin Naomi HuangLaboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute Bethesda Maryland 20892 USA.
Ekaterina I GoncharovaMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.
Dongdong WangMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.ORCID https://orcid.org/0000-0002-7824-2507
Yves PommierLaboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute Bethesda Maryland 20892 USA.
Barry R O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.ORCID https://orcid.org/0000-0003-0772-4856
Lin DuMolecular Targets Program, Center for Cancer Research, National Cancer Institute Frederick Maryland 21702-1201 USA dul2@mail.nih.gov.ORCID https://orcid.org/0000-0001-8751-4482

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI PENDLETON, RICHARD · 2019 to 2025
$3932.6M
CCR NIH HHS HHSN261200800001CNIH HHS 75N91019D00024NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

A cell viability screen was conducted to identify natural products whose cytotoxicity depends on the presence or absence of topoisomerase 3β (TOP3B), the only known mammalian topoisomerase with the ability to resolve both DNA and RNA topological structures. Bioassay-guided fractionation of the organic solvent extract of

Identifiers

PMID42904217
PMCPMC13682530

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.