ArticleResuscitation plus2026
Brain edema progression rate on serial CT predicts neurological outcome after cardiac arrest: a region-specific biomarker of hypoxic-ischemic brain injury.
Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To evaluate the prognostic performance of the attenuation change rate on serial brain computed tomography (CT), a novel quantitative marker of temporal cerebral attenuation change, for predicting poor neurological outcome after cardiac arrest (CA). Methods: This was a retrospective analysis of a prospective cohort. CA patients who underwent cranial CT both within 12 h and between 12 h and one week after return of spontaneous circulation (ROSC) were included. The attenuation change rate, calculated as the HU difference between paired scans divided by the time interval, was measured in 12 predefined brain regions. Neurological outcome was assessed using the Cerebral Performance Category (CPC) at discharge. Results: Of 53 patients enrolled, 17 (32.1%) had favorable neurological outcomes at discharge. Patients with poor outcomes exhibited significantly greater attenuation decline rates in all gray matter regions except for gray matter at the centrum semiovale level, including the caudate nucleus (-0.01 vs. 0.02 HU/h), putamen (-0.02 vs. 0 HU/h), thalamus (-0.02 vs. 0.01 HU/h), gray matter of the high convexity (-0.02 vs. 0 HU/h), and cerebellar gray matter (-0.02 vs. 0.03 HU/h) (all Conclusion: Serial CT-derived attenuation change rate may serve as an exploratory quantitative marker of cerebral edema progression after cardiac arrest. However, this single-center, small-sample study does not support its use for withdrawal of life-sustaining treatment decisions. Multicenter validation is warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.