Evidence map›Paper›PMID 42904179›Full record

ArticleiScience2026

Single-cell mapping of human plasma cell fate reveals a commitment checkpoint and Cav-1β expression associated with mTORC1 machinery.

Gersende Caron, Fabienne Desmots, Mélanie Chabaud, Maud Lemarié, Vincent Olivier, Fabrice Chatonnet, Céline Nonn, Cassandra Jadeau, Simon Léonard, Céline Monvoisin and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Gersende CaronUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Fabienne DesmotsUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Mélanie ChabaudUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Maud LemariéUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Vincent OlivierUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Fabrice ChatonnetUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Céline NonnUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Cassandra JadeauLaboratoire d'hématologie, Pôle de Biologie, Centre Hospitalier Universitaire, 35033 Rennes, France.
Simon LéonardUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Céline MonvoisinUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Kathleen SantamariaUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Cédric M BlouinInstitut Curie - Centre de Recherche, PSL Research University, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Paris, France.
Noudjoud AttafInstitut National de la Santé et de la Recherche Médicale (INSERM), U1339 Paris, France.
Tarek GharsalliInstitut National de la Santé et de la Recherche Médicale (INSERM), U1339 Paris, France.
Pierre MilpiedAix Marseille University, CNRS, Inserm, CIML, Marseille, France.
Christophe LamazeInstitut Curie - Centre de Recherche, PSL Research University, Membrane Mechanics and Dynamics of Intracellular Signaling Laboratory, Paris, France.
Céline PangaultUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Marion HaasUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.
Thierry FestUniversité de Rennes 1, INSERM, Établissement Français du Sang de Bretagne, UMR_S1236, 35043 Rennes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human B cell differentiation into antibody-secreting plasma cells (PCs) requires coordinated transcriptional and organelle remodeling. Using single-cell transcriptomics in an

Indexed as

endoplasmic reticulum, secretory machinery, and nutrient-sensing complexeshuman B cell differentiationnon-caveolar Cav-1βplasma cell differentiationsingle-cell resolution mapping human plasma cell differentiationV-ATPase-RAGulator pathwayXBP1-driven induction of CAV1

Identifiers

PMID42904179
PMCPMC13682384

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.