ArticleJournal of inflammation research2026
Network Pharmacology and Experimental Evidence Indicate That Dihydrochelerythrine from
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Methods: Active compounds and candidate targets were screened by network pharmacology and molecular docking. Male Sprague-Dawley rats with monosodium iodoacetate-induced KOA received DHCHE (2.5 or 5 mg/kg) by oral gavage once daily for 28 days, beginning 7 days after model induction. Knee joints were assessed by micro-computed tomography, hematoxylin-eosin staining, Safranin O-fast green staining with positive-area quantification, and Western blotting. Results: Network pharmacology prioritized DHCHE, with AKT1, EGFR, and SRC ranking among the core targets. MIA-induced KOA markedly disrupted subchondral bone microarchitecture. BV/TV and BMD were lower than in Sham rats, whereas SMI was higher (all Conclusion: DHCHE ameliorated subchondral bone microstructural and cartilage pathological changes in MIA-induced KOA rats. The accompanying reductions in phosphorylated EGFR, PI3K, and AKT signals were associated with this signaling axis, but direct target engagement and causality were not established.
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