Evidence map›Paper›PMID 42904144›Full record

ArticleiScience2026

Graphene-oxide-microfiber aptasensor for dynamic neutrophil monitoring: Bridging cytokine release syndrome and point-of-care sepsis diagnosis.

Zhiheng Yu, Heshuang Dong, Xiaolin Chen, Mengjiang Xu, Ren Liu, Jingjing Wang, Cunliang Yang, Ke Wang, Xianyuan Zhao, Hao Jia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiheng YuShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Heshuang DongShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xiaolin ChenFaculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Mengjiang XuFaculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ren LiuShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Jingjing WangShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Cunliang YangShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Ke WangShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Xianyuan ZhaoDepartment of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200120, China.
Hao JiaQingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.
Jijun FengShanghai Key Laboratory of Modern Optical System, Engineering Research Center of Optical Instrument and System (Ministry of Education), School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophil granule release is critical for host defense, yet its dysregulation underpins cytokine release syndrome (CRS) in both acute (such as sepsis) and sustained inflammatory states. Distinguishing these phases requires real-time monitoring of early markers like neutrophil elastase (ELANE) and lactoferrin (LF), but conventional assays lack requisite sensitivity. Here, we developed a graphene-oxide-functionalized optical microfiber biosensor with high-affinity DNA aptamers (NE-AP and LF-AP) to quantify ELANE and LF via aptamer-protein binding-induced spectral red shifts. The sensor achieved ultralow detection limits (3.57 × 10

Indexed as

early sepsis diagnosisgraphene oxidelactoferrinneutrophil elastaseoptical microfibers

Identifiers

PMID42904144
PMCPMC13682345

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.