Evidence map›Paper›PMID 42904134›Full record

ArticlePhysics and imaging in radiation oncology2026

Benchmarking intermediate dose spillage in single target stereotactic radiosurgery for brain metastases.

Youness Nour, Shari Wiegreffe, Tuba Tekin, Lara Caglayan, Christina Leitzen, Cas S Dejonckheere, Davide Scafa, Julian P Layer, Victoria Volkenborn, Fabian Kugel and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Youness NourDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Shari WiegreffeDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Tuba TekinDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Lara CaglayanDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Christina LeitzenDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Cas S DejonckheereDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Davide ScafaDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Julian P LayerDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Victoria VolkenbornDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Fabian KugelDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Stephan GarbeDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Christos MoustakisDepartment of Radiation Physics, University Hospital Leipzig, Stephanstrasse 9a, Leipzig, Germany.
Dimos BaltasDepartment of Radiation Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Gustavo R SarriaDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.
Anca-L GrosuDepartment of Radiation Oncology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Eleni GkikaDepartment of Radiation Oncology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Intermediate-dose spillage is central to normal-brain sparing in stereotactic radiosurgery, yet fixed adverse-event and relative indices do not define achievable plan quality for single-target linear accelerator treatments. The aim was to derive a volume-dependent absolute benchmark for the 50% prescription isodose volume (V Materials and methods: In total, 276 single-isocenter single-target plans were analyzed: 178 idealized model plans and 98 clinical plans. Power-law regression in log-log space modeled spillage against planning target volume (PTV, cm Results: In the model cohort V Conclusions: A volume-based V

Indexed as

Brain metastasesDose gradientIntermediate-dose spillageQuality assuranceStereotactic radiosurgery

Identifiers

PMID42904134
PMCPMC13682193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.