Evidence map›Paper›PMID 42904109›Full record

ArticleSynthetic and systems biotechnology2027

A base-editing and auxotrophic selection platform for linking epigenetic regulators to silent biosynthetic gene clusters in

Meng Pang, Donghui Guo, Yanling Li, Yuze Chen, Rumeng Du, Jiayang Liu, Jiahui Hu, Hang Li, Zhuofan Li, Guojun Pan and 2 more

Abstract read
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In one paragraph

Article in Synthetic and systems biotechnology, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meng PangSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Donghui GuoSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Yanling LiSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Yuze ChenSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Rumeng DuSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Jiayang LiuSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Jiahui HuSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Hang LiSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Zhuofan LiSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Guojun PanSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Yuan TianSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.
Fanglong ZhaoSchool of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong, 271016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Filamentous fungi harbor numerous silent biosynthetic gene clusters (BGCs), representing an underexplored reservoir of natural products. Chemical inhibition of epigenetic regulators is an effective strategy for activating silent BGCs, but it often lacks specificity and cannot readily link activated clusters to their cognate regulators. Here, we developed a coupled cytosine base editing and auxotrophic selection platform in

Indexed as

Activation of silent gene clustersAspergillus nidulansBase editing screenEpigenetic regulationPolyketide synthase

Identifiers

PMID42904109
PMCPMC13682063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.