Evidence map›Paper›PMID 42904106›Full record

ArticleBiochemistry and biophysics reports2026

Med1 deletion reprograms dental epithelium into a hair-forming epidermal architecture associated with Trp63 induction.

Roman Thaler, Yuta Chiba, Zhiyun Lin, Sun Hee Won Kim, Satoshi Fukumoto, Pamela Den Besten, Daniel D Bikle, Keigo Yoshizaki, Yuko Oda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roman ThalerDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.
Yuta ChibaDivision of Pediatric Dentistry, Department of Community Social Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Zhiyun LinDepartments of Medicine and Endocrinology, University of California San Francisco and San Francisco Veterans Affairs Health Center, CA, USA.
Sun Hee Won KimDepartments of Medicine and Endocrinology, University of California San Francisco and San Francisco Veterans Affairs Health Center, CA, USA.
Satoshi FukumotoDivision of Pediatric Dentistry, Department of Community Social Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Pamela Den BestenDepartment of Dentistry, University of California San Francisco, CA, USA.
Daniel D BikleDepartments of Medicine and Endocrinology, University of California San Francisco and San Francisco Veterans Affairs Health Center, CA, USA.
Keigo YoshizakiSection of Orthodontics and Dentofacial Orthopedics, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Yuko OdaDepartments of Medicine and Endocrinology, University of California San Francisco and San Francisco Veterans Affairs Health Center, CA, USA.

Funding

Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
The role of Med1 in dental stem cell fateR21DE025357 · NIDCR · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ODA, YUKO · 2016 to 2017
$422k
BLRD VA I01 BX003814BLRD VA I01 BX005854NIAMS NIH HHS R01 AR050023NIDCR NIH HHS R21 DE025357
6 · The paper itself

Abstract

Ectodermal fate decisions between tooth enamel and skin hair are governed by transcriptional regulation and tissue architecture. Deletion of the Mediator subunit

Identifiers

PMID42904106
PMCPMC13682057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.