Ferric pyrophosphate in precision iron fortification: mechanistic insights into food-system suitability, bioavailability modulation, and evaluation strategies.

Yuqi Wang, Yunshan Wei, Mengwei Chang, Junhee No, Kunlun Liu

Abstract readReview

In one paragraph

Review in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yuqi WangCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, PR China.

Yunshan WeiCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, PR China.

Mengwei ChangCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, PR China.

Junhee NoDepartment of Food Science and Nutrition, Kyungpook National University, Daegu 41566, South Korea.

Kunlun LiuCollege of Food Science and Engineering, Henan University of Technology, Zhengzhou, Henan 450001, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is an essential trace nutrient, and iron deficiency remains a major global public health problem. Iron-fortified foods are important vehicles for preventive iron supplementation. Precision iron fortification requires matching iron sources to specific food matrices to balance product quality and fortification efficacy. Ferric pyrophosphate (FePP) shows good food-system stability and gastrointestinal tolerability, but low solubility and limited bioavailability restrict wider application. This review addresses FePP food-system suitability, bioavailability modulation, and evaluation strategies, summarizing physicochemical modification, delivery systems, and absorption-oriented dietary modulation. These approaches improve dispersion and dissolution, control gastrointestinal release and transport, and mediate nutrient effects on Fe

Indexed as

BioavailabilityFerric pyrophosphateFortified foodsModification technology

Identifiers

PMID42904102

DOI10.1016/j.fochx.2026.104600

PMCPMC13682029

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.