Evidence map›Paper›PMID 42904030›Full record

ArticlehLife2024

Mahalakshmi Shanmugasundaram, Simin Xu, Yujie Yang, Jong Huat Tee, Terence Yin Weng Lam, Ruowen Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in hLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mahalakshmi ShanmugasundaramDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
Simin XuDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
Yujie YangDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
Jong Huat TeeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
Terence Yin Weng LamDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.
Ruowen GeDepartment of Biological Sciences, Faculty of Science, National University of Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease with high morbidity and mortality but unclear etiology and incomplete pathophysiological understandings, making the discovery of effective therapeutics arduous. Currently, two drugs, nintedanib and pirfenidone, are available for IPF treatment which can slow down the fibrotic scarring in the lung but are unable to provide disease resolution. Hence, further revelation of the molecular mechanisms of IPF is critical for the development of novel therapeutics. Isthmin-1 (ISM1) is a secreted anti-inflammatory protein highly expressed in the mouse and human lung.

Indexed as

anti-inflammationcellular senescenceisthmin-1 (ISM1)lipid metabolismlipofibroblastpulmonary fibrosis

Identifiers

PMID42904030
PMCPMC13681647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.