Evidence map›Paper›PMID 42904019›Full record

ArticleInflammatory intestinal diseases

Biopsy-Confirmed Serofrequency of Celiac Disease among Patients with Disorders of Gut-Brain Interaction in Japan: A Multicenter Cross-Sectional Cohort Study.

Masaaki Higashiyama, Chie Kurihara, Akiko Shiotani, Takeshi Mizukami, Mikihiro Fujiya, Akihito Nagahara, Seiji Futagami, Hiroyuki Imaeda, Eikichi Ihara, Katsunori Iijima and 17 more

Abstract read
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In one paragraph

Article in Inflammatory intestinal diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Masaaki HigashiyamaDepartment of Internal Medicine, National Defense Medical College, Saitama, Japan.ORCID https://orcid.org/0000-0002-3206-4055
Chie KuriharaDepartment of Internal Medicine, National Defense Medical College, Saitama, Japan.
Akiko ShiotaniDepartment of Gastroenterology and Hepatology, Kawasaki Medical School, Okayama, Japan.
Takeshi MizukamiDepartment of Endoscopy Center, NHO Kurihama Medical and Addiction Center, Yokosuka, Japan.
Mikihiro FujiyaDivision of Gastroenterology, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.ORCID https://orcid.org/0000-0002-4321-7774
Akihito NagaharaDepartments of Gastroenterology, Juntendo University Faculty of Medicine, Tokyo, Japan.
Seiji FutagamiDivision of Gastroenterology, Nippon Medical School, Tokyo, Japan.
Hiroyuki ImaedaDepartment of Gastroenterology, Saitama Medical University, Saitama, Japan.
Eikichi IharaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Katsunori IijimaDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Shuji TeraiDivision of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Yasuhiro FujiwaraDepartment of Gastroenterology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Akira AndohDepartment of Medicine, Shiga University of Medical Science, Otsu, Japan.
Naoki OhmiyaDepartment of Advanced Endoscopy, Fujita Health University School of Medicine, Aichi, Japan.ORCID https://orcid.org/0000-0002-7651-402X
Hiromi KataokaDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Tadayuki OshimaDepartment of Gastroenterology and Hepatology, Hyogo Medical University, Hyogo, Japan.
Takayuki MatsumotoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.ORCID https://orcid.org/0000-0001-9786-3854
Hiroshi NakaseDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.ORCID https://orcid.org/0000-0003-2848-6586
Hirotake SakurabaDepartment of Gastroenterology, Hematology and Clinical Immunology, Hirosaki University Graduate School of Medicine, Aomori, Japan.ORCID https://orcid.org/0000-0002-6075-1282
Mamoru WatanabeOrganoid Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Kazushige UchidaDepartment of Gastroenterology and Hepatology, Kochi Medical School, Kochi University, Kochi, Japan.
Hidekazu SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Masanao NakamuraDepartment of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Aichi, Japan.
Yoshikazu KinoshitaHyogo-prefectural Harima-Himeji General Medical Center, Himeji, Japan.
Govind K MakhariaDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
Ryota HokariDepartment of Internal Medicine, National Defense Medical College, Saitama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: While celiac disease (CeD) is an emerging disease worldwide, its prevalence has traditionally been very low in Japan. However, there are no regional data available regarding CeD across Japan. In this study, we screened patients with disorders of gut-brain interaction (DGBI), including irritable bowel syndrome (IBS) and functional dyspepsia (FD), who were supposedly at a high risk for CeD. Subjects were enrolled from the Hokkaido area (northern Japan) to the Kyushu area (southern Japan) to determine the biopsy-confirmed serofrequency of CeD across Japan and its regional distribution. Methods: In this study, adult patients fulfilling the criteria for IBS or FD were recruited from the outpatient departments of 23 participating centers in Japan. Anti-tissue transglutaminase IgA (TTG) titers were determined for serological screening. Further histological studies were performed in patients with TTG levels >10 u/mL. Results: In total, 583 patients were enrolled in this study. There was only one subject with TTG >10 u/mL among the subjects with diarrhea-predominant IBS, who was histologically diagnosed with CeD of Marsh 3a. Biopsy-confirmed serofrequency was estimated to be 0.17% among DGBI in Japan. The regional distribution was not evaluated because of its rarity. Conclusion: It is noteworthy that no clustering of CeD cases in Japanese patients with DGBI was observed, and the overall frequency remained extremely low across all participating centers nationwide.

Indexed as

Celiac diseaseFunctional dyspepsiaIgA tissue transglutaminaseIrritable bowel syndrome

Identifiers

PMID42904019
PMCPMC13682709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.