Evidence map›Paper›PMID 42903988›Full record

ArticlehLife2026

Placental endothelial ferroptosis induced by neutrophil NETosis leads to intrauterine growth restriction in dengue virus infection.

Ziyang Sheng, Jiaying Cao, Hao Zhang, Yuetong Li, Yingying Zhang, Han Wang, Feiyang Xue, Shiqi He, Na Gao, Dongying Fan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in hLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ziyang ShengDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jiaying CaoDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Hao ZhangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yuetong LiDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yingying ZhangDepartment of Blood Transfusion, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.
Han WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Feiyang XueDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Shiqi HeDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Na GaoDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Dongying FanDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Peigang WangDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Jing AnDepartment of Microbiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies on dengue virus (DENV) infection during pregnancy show that symptomatic dengue is associated with adverse fetal outcomes, but the mechanisms remain unclear. Our previous research indicated that neutrophils contribute to intrauterine growth restriction (IUGR) by damaging placental vasculature, yet the molecular mechanisms underlying this microvascular injury remain poorly defined. To address this, this study examined placental microvascular ferroptosis by bulk and single-cell transcriptomic reanalyses, immunofluorescence staining, and Western blotting in DENV-2-infected E18.5 placentas from pregnant

Indexed as

dengue virusferroptosisintrauterine growth restrictionoxidative stressplacental vascular endothelial cellsingle-cell RNA sequencing

Identifiers

PMID42903988
PMCPMC13681620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.