ArticleRoyal Society open science2026
Recent advances in protein extraction methods from bone tissue for proteomics analysis.
Article in Royal Society open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Proteomic analysis is a fundamental tool for obtaining new information about biological functions that occur at the molecular level in the body, allowing the understanding of physiological and pathological processes, as well as contributing to the diagnosis and prevention of diseases. However, a critical step for the success of these analyses is the protein extraction from the tissue of interest, with well-described and reproducible protocols still scarce in the current literature, especially for bone tissues. Therefore, the main objective of this study was to present a reliable and standardized methodology for protein extraction from hard tissue samples. The methodology employed was based on an extraction protocol using demineralized bone tissue, with more detailed experimental parameters such as incubation times, temperatures and sample storage conditions. As a result, 1429 proteins previously described for the species
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