Evidence map›Paper›PMID 42903966›Full record

ReviewhLife2025

Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy.

Zhaokai Zhou, Yingying Lv, Anning Zuo, Xudong Zhu, Yudi Xu, Lulu Zuo, Hui Xu, Shutong Liu, Yuyuan Zhang, Siyuan Weng and 14 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in hLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Zhaokai ZhouDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yingying LvDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Anning ZuoDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Xudong ZhuMarkey Cancer Center, University of Kentucky, Kentucky, USA.
Yudi XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Lulu ZuoCenter of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Hui XuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Shutong LiuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yuyuan ZhangDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Siyuan WengDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yuhao BaDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Peng LuoThe Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangdong, China.
Quan ChengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Hunan, China.
Jiaxin XuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Xing ZhouDepartment of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Shuang ChenCenter of Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Boxuan LiDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Chuhan ZhangDepartment of Oncology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Yukang ChenDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Jinhai DengRichard Dimbleby Department of Cancer Research, Comprehensive Cancer Centre, Kings College London, London, UK.
Xiulin JiangDepartment of Medicine, Health Cancer Center, University of Florida, Florida, USA.
Zaoqu LiuDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.
Ran XuDepartment of Urology, The Second Xiangya Hospital of Central South University, Hunan, China.
Xinwei HanDepartment of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human microbiota constitute a complex and dynamic community that interacts with the innate immunity of the host at various anatomical sites, influencing both physiological and pathological states. In individuals with a genetic predisposition, disruptions to the "innate immunity‒microbiota" axis appear to rewire immune responses within the tumor microenvironment (TME), thereby driving cancer pathogenesis. This review summarizes the intricate crosstalk between the microbiota and innate immunity in both healthy and cancerous states, focusing on the modulation of immune recognition and polarization during tumor progression, including immune escape, barrier disruption, chronic inflammatory transformation, and angiogenesis in the initiation phase, as well as the regulation of local invasion, vascular invasion, and pre-metastatic ecological niche formation involved in the metastatic phase. This review also highlights recent advances and challenges in leveraging microbiota for cancer immunotherapy, covering innovations in bacteriophages, genetically engineered probiotics, and bioinformatic applications. Moreover, this review proposes potential approaches to enhance therapeutic efficacy by targeting innate immunity‒microbiota interactions. Further mechanistic insights into these interactions may pave the way for developing innovative microbiota-based cancer immunotherapies.

Indexed as

bioinformaticsimmunotherapyinnate immunitymicrobiotapolarizationtumor microenvironment

Identifiers

PMID42903966
PMCPMC13681622

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.