Severe fever with thrombocytopenia syndrome-associated encephalitis and intracranial hypotension: A case report.

Peibing Zheng, Yao Zhang, Liuping Hu, Peng Wang, Yanhong Xu

Abstract readCase Reports

In one paragraph

Article in Infectious diseases & immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Peibing ZhengDepartment of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Yao ZhangDepartment of Hematology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Liuping HuClinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Peng WangDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Yanhong XuDepartment of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a natural infectious disease caused by severe fever with thrombocytopenia syndrome virus (SFTSV). Central nervous system (CNS) involvement is not rare in SFTS. In this work, we report a case of SFTS with CNS symptom onset and the metagenomic next-generation sequencing of cerebrospinal fluid (CSF), confirming invasion of SFTSV into the CNS. The case's lumbar puncture indicated an exceptionally low CSF opening pressure-an uncommon finding in other CNS infections and in case reports of SFTS. A spontaneous subdural effusion was observed on the fourth day of hospitalization. Moreover, a flow cytometry analysis of bone marrow revealed a restricted expression of the lambda light chain in monoclonal B cells and plasma cells. The patient succumbed to their severe illness. The early recognition of the disease may be crucial for prognosis despite the disease's current lack of specific treatments.

Indexed as

Intracranial hypotensionSevere fever with thrombocytopenia syndromeSFTS-associated encephalitisSubdural effusion

Identifiers

PMID42903953

DOI10.1097/ID9.0000000000000209

PMCPMC13682816

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