ArticleRSC chemical biology2026
Bromo-desthiobiotin (Br-DTB) tag for unbiased profiling and identification of chemical modifications.
Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Leveraging the intrinsic reactivity of cysteine, isoTOP-ABPP (activity-based protein profiling) has been a powerful chemoproteomic platform for cysteine quantification, ligand, and chemical modification discovery. Here, we report new bromo-desthiobiotin azide (Br-DTB) tags for covalent labelling, enabling unbiased identification of chemical modifications. Besides peptide identification from MS2 spectra, Br's isotopic MS1 signatures provide an additional layer of validation to confirm labelled sites and eliminate false-positive assignments. To support this analysis, we have developed a publicly available in-house software to automatically recognize this isotopic signature. The accuracy of the Br-DTB tag was further validated by a synthetic peptide
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.