Evidence map›Paper›PMID 42903858›Full record

ReviewJournal of orthopaedic translation2026

The emerging role of subchondral bone homeostasis in osteoarthritis.

Antonia Donat, Weixin Xie, Assil-Ramin Alimy, Anke Baranowsky, Tim Rolvien, Johannes Keller

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonia DonatMusculoskeletal University Center Munich, Ludwig-Maximilians-University Munich (LMU), Marchioninistr. 15, Munich, 81377, Germany.
Weixin XieDepartment of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.
Assil-Ramin AlimyDepartment of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.
Anke BaranowskyDepartment of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.
Tim RolvienDepartment of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.
Johannes KellerDepartment of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of progressive articular cartilage degeneration and consequent joint deterioration, also known as osteoarthritis (OA), remains a major challenge in musculoskeletal medicine. The subchondral bone has become a key area of research, as early alterations in bone remodelling and structure may precede cartilage degeneration and contribute to disease initiation and progression. Therefore, this review aims to summarise our current understanding of the role of subchondral bone in the initiation and progression of OA. Scientific databases were analysed, focusing on studies published within the last 15 years. Both preclinical

Indexed as

CrosstalkJoint diseaseOsteoarthritisPIEZO1RANKLSubchondral bone

Identifiers

PMID42903858
PMCPMC13681461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.