ArticleMolecular & cellular oncology2026
GINS1 suppresses ferroptosis by inhibiting the Hippo pathway in neuroblastoma.
Article in Molecular & cellular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Neuroblastoma (NBL) prognosis remains poor in high-risk cases. Ferroptosis is a promising therapeutic target, but its regulation in NBL is unclear. This study investigates GINS1's role in NBL ferroptosis. Methods: Bioinformatics analysis (GSE49710, GSE73517, TARGET) assessed GINS1 expression and prognosis. In vitro, GINS1 was knocked down in SH-SY5Y and SK-N-SH cells. Proliferation (CCK-8), migration (Transwell), apoptosis, and ferroptosis markers (lipid peroxidation, Fe Results: GINS1 knockdown in SH-SY5Y and SK-N-SH cells inhibited proliferation (60% reduction in SH-SY5Y cells and 55% in SK-N-SH cells, Conclusion: GINS1 suppresses ferroptosis via Hippo pathway inhibition and YAP activation, leading to ACSL4 repression. GINS1 is a potential prognostic biomarker and therapeutic target in high-risk NBL.
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