Evidence map›Paper›PMID 42903835›Full record

ReviewFrontiers in immunology2026

Extracellular vesicle-mediated immune remodeling in cutaneous wound repair.

Gun Woo Lee, Wook-Tae Park, Min-Soo Seo, Sangbum Park

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gun Woo Lee *Department of Orthopedic Surgery, Ulsan Medical Center, Ulsan, Republic of Korea.
Wook-Tae Park *Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Min-Soo Seo *Laboratory of Veterinary Tissue Engineering, College of Veterinary Medicine, Kyungpook National University, Daegu,Republic of Korea.
Sangbum Park *Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, United States.

Funding

Understanding immune-epithelial interactions during wound repair in live mammalsR01AR083086 · NIAMS · MICHIGAN STATE UNIVERSITY · PI Sangbum Park · 2023 to 2026
$1.9M
NIAMS NIH HHS R01 AR083086
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are emerging cell-free therapeutic platforms for cutaneous wound repair that regulate diverse cellular processes, including intercellular communication, inflammation, angiogenesis, extracellular matrix remodeling, and tissue repair. Recent advances in parental cell preconditioning, EV engineering, smart EV design, and biomaterial-assisted delivery have further enhanced the therapeutic potential of EV-based approaches. These advances have stimulated growing interest in applying EVs to skin wound repair, where EVs act on resident skin cells and immune cells to promote regenerative healing. In particular, macrophage reprogramming is well characterized, whereas EV-mediated regulation of other immune-cell populations remains less clearly defined. Standardized EV production, reliable potency assays, and dynamic

Indexed as

Extracellular VesiclesSkinWound HealingAnimalsHumansRegenerationextracellular vesiclesimmune remodelinginflammationskin regenerationwound healing

Identifiers

PMID42903835
PMCPMC13682443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.