Evidence map›Paper›PMID 42903822›Full record

ReviewCurrent research in food science2026

Microfluidic intestinal-chips as next-generation modeling strategies: Multifaceted emerging applications in food research, functional foods and personalized nutrition.

Junli Feng, Hejian Zhu, Yan Peng, Liqin Lin, Jingzi Yao, Xiuqin Fan, Jiayan Shen, Jing Xue, Zejun Wang, Guofang Shen and 1 more

Abstract readReview
In one paragraph

Review in Current research in food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Junli FengZhejiang Key Laboratory of Food Microbiology and Nutritional Health, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, 310018, China.
Hejian ZhuZhejiang Key Laboratory of Food Microbiology and Nutritional Health, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, 310018, China.
Yan PengHangzhou Institute for Food and Drug Control, Hangzhou, 310022, China.
Liqin LinHangzhou Institute for Food and Drug Control, Hangzhou, 310022, China.
Jingzi YaoDepartment of Surgery, Jinhua Traditional Chinese Medicine Hospital, Jinhua, Zhejiang, 321000, China.
Xiuqin FanKey Laboratory of Medicine-Food Homology Innovation and Transformation, Department of Gastroenterology, Hangzhou Linping District Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, 311100, China.
Jiayan ShenKey Laboratory of Medicine-Food Homology Innovation and Transformation, Department of Gastroenterology, Hangzhou Linping District Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, 311100, China.
Jing XueZhejiang Key Laboratory of Food Microbiology and Nutritional Health, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, 310018, China.
Zejun WangZhejiang Key Laboratory of Food Microbiology and Nutritional Health, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, 310018, China.
Guofang ShenHangzhou Institute for Food and Drug Control, Hangzhou, 310022, China.
Qing ShenPanvascular Diseases Research Center, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, 324000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food digestion and absorption are essential functions of the human gut and the cornerstone of food research. This article has reviewed the core modeling strategies of intestinal-chips, and their application in the field of food science research, including precise evaluation of nutritional efficacy, food safety risk prediction, innovative development of functional foods and construction of personalized nutritional intervention strategies. Although microfluidic intestinal-chips have addressed some limitations inherent to traditional models, they still face technical challenges in fully replicating the intestinal microenvironment, as well as neural innervation, vascular perfusion and systemic immune responses. Currently, intestinal-chips are accelerating their integration with advanced technologies such as biomaterials, stem cell science, gene editing, 3-D bioprinting and artificial intelligence, to continuously enhance the physiological fidelity, support the optimization of food processing techniques and accelerate the development of new functional foods. These advancements of intestinal-chips won't only substantially promote the industrialization of next-generation food innovations such as cell-cultured meat and synthetic biology foods, but also drive nutritional science research from group recommendations to individualized decision-making. This technology thus provides an indispensable

Indexed as

Dietary nutrientInnovation strategyIn vitro modelMicrofluidic intestinal-chipPrecise nutrition

Identifiers

PMID42903822
PMCPMC13682349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.