ArticleJournal of hepatocellular carcinoma2026
Negative Correlation Between ADC Values and GPC3 Expression in Hepatocellular Carcinoma: A Quantitative Diffusion-Weighted Imaging Study.
Article in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the association between apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging (DWI) and glypican-3 (GPC3) expression in hepatocellular carcinoma (HCC), and to explore the potential of ADC as a non-invasive imaging biomarker for assessing GPC3 expression. Methods: This retrospective study included 468 patients with pathologically confirmed HCC who underwent preoperative liver magnetic resonance imaging between January 2020 and December 2025. Based on immunohistochemical staining, patients were classified into three groups: GPC3-negative (GPC3-, n=69), low-expression (GPC3+, n=42), and high-expression (GPC3++, n=357). Tumor ADC values, adjacent liver tissue ADC values, and tumor-to-liver ADC ratios were measured and compared among groups. Statistical analyses included the Kruskal-Wallis test, Mann-Whitney Results: Tumor ADC values differed significantly among the three groups (p<0.001), with median ADC values of 1.40 (1.34-1.46), 1.35 (1.28-1.42), and 1.27 (1.23-1.31) ×10 Conclusion: Higher GPC3 expression in HCC was associated with lower tumor ADC values. Quantitative DWI-derived ADC, including both tumor ADC and the tumor-to-liver ADC ratio, may serve as a promising imaging biomarker associated with GPC3 expression, potentially offering supportive information for preoperative evaluation of HCC.
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