ArticleiScience2026
IκBζ target genes in chronic lymphocytic leukemia.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
15 authors.
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Abstract
IκBζ, an atypical IκB protein induced downstream of Toll-like receptor (TLR) signaling, is pivotal in orchestrating inflammatory responses and modulating inflammation-associated B cell malignancies. However, the transcriptional and epigenetic programs regulated by IκBζ in both normal and malignant B cells remain poorly described. Here, we analyzed chronic lymphocytic leukemia (CLL) cells by epigenomic profiling to dissect the molecular function of IκBζ in leukemia. In primary human B cells and CLL samples, chromatin immunoprecipitation sequencing (ChIP-seq) and cleavage under targets and tagmentation (CUT&Tag) analyses delineated a comprehensive genome-wide landscape of IκBζ binding sites. Key genes, including
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