Mitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.

Liyuan Xue, Kai Cao, Mingyang Du, Yaqi Jiang, Dongfang Xia, Liang Gao, Cuicui Ji, Xueyun Gao

Abstract read

In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liyuan XueCollege of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.

Kai CaoCollege of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.ORCID https://orcid.org/0000-0002-7939-7279

Mingyang DuDepartment of Biology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.

Yaqi JiangCenter of Excellence for Environmental Safety and Biological Effects, Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.

Dongfang XiaCollege of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.

Liang GaoCollege of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.ORCID https://orcid.org/0000-0002-9337-345X

Cuicui JiDepartment of Biology, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.

Xueyun GaoCollege of Materials Science and Engineering, Beijing University of Technology, Beijing 100124, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Premature ovarian insufficiency (POI), often induced by environmental pollutants such as 4-vinylcyclohexene diepoxide (VCD), is a growing clinical concern, with limited treatment options. Here, we report a nanotherapeutic strategy using a rationally designed ultrasmall gold nanoparticle templated with reduced glutathione (GGNP). GGNPs effectively alleviate VCD-induced granulosa cell aging through scavenging mitochondrial reactive oxygen species and activating mitophagy. This concomitant effect restores mitochondrial function and prevents mitochondrial DNA release, thereby suppressing the downstream STING-mediated senescence-associated secretory phenotype (SASP) pathway. In a VCD-induced POI mouse model, GGNP administration significantly reverses both ovarian and uterine atrophy, normalizes follicle-stimulating hormone levels, and inhibits SASP signaling without detectable toxicity. Our study thus establishes GGNP as a promising nanomedicine for environmental pollutant-induced POI by restoring mitochondrial homeostasis.

Indexed as

environmental pollutantgold nanoparticlemitochondrial damagemitophagypremature ovarian insufficiencySASP

Identifiers

PMID42903735

DOI10.1021/envhealth.6c00186

PMCPMC13681436

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.