ReviewFrontiers in immunology2026
Hydrogel-based reprogramming of the tumor inflammatory microenvironment: from mechanotransduction and dynamic materials to adaptive immunotherapy.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Modulating inflammation within the tumor microenvironment (TME) has emerged as a crucial avenue in contemporary cancer therapy. However, the intricate signaling networks, mechanical heterogeneity, spatiotemporal drug gradients, and poor immune cell infiltration continue to hinder the effectiveness of conventional therapeutic strategies. Hydrogels, with tunable physicochemical properties and versatile biological functions, offer a promising platform for addressing these challenges. This review first unpacks the inflammatory pathways active in the TME and then provides a structured overview of hydrogel classifications and material characteristics. From there, it discusses how mechanotransduction pathways (e.g., YAP/TAZ, Piezo1, FAK) and chemical signaling frameworks shape the interaction between hydrogels and the TME. In addition, the article highlights hydrogels' translational potential by outlining their roles in inflammation-associated biomarker detection, precision drug delivery systems, and
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