SynthesisFrontiers in neurology2026
Comparative effects and dose-response relationships of exercise for finger dexterity and upper-limb function in Parkinson's disease: a Bayesian network and model-based dose-response meta-analysis.
Synthesis in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Background: Upper-limb impairment limits independence in Parkinson's disease (PD), but the comparative effects and dose-response profiles of exercise modalities remain uncertain. Methods: PubMed, Embase, CENTRAL, Web of Science, Scopus, and SPORTDiscus were searched from inception to June 20, 2026. Studies that qualified were randomized controlled trials of structured exercise or rehabilitation in adults with PD. Bayesian random-effects network meta-analysis and model-based dose-response network meta-analysis were conducted separately for finger dexterity and upper-limb function. Weekly dose was expressed as metabolic equivalent of task minutes per week (MET·min/week), and evidence certainty was assessed using CINeMA. Results: Thirty-six reports comprising 1,575 participants were included. Aerobic exercise training (Hedges' Conclusion: Exercise effects were outcome specific. The findings can inform exercise-modality selection and future dose-ranging trials, but they do not establish an optimal dose or justify a uniform clinical prescription. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261463560, identifier: CRD420261463560.
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