ReviewFrontiers in neuroscience2026
Context-dependent oxytocin receptor signaling: from molecular architecture to transcript-level receptor engineering.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
The oxytocin receptor (OXTR) is a G protein-coupled receptor that integrates neuroendocrine release, cellular signaling, and behavioral effects across species. Despite extensive research, the mechanistic basis underlying variability in oxytocin's effects remains incompletely understood. This review synthesizes recent advances in OXTR biology and focuses on three biological sources of signaling heterogeneity: variation in receptor sequence and structure, epigenetic and cell-state-dependent regulation, and temporal patterns of receptor activation. It examines targeted manipulation of receptor transcripts as an experimental strategy for testing intracellular mechanisms with behavioral outcomes. Mechanistic studies show that subtle structural changes, including single nucleotide polymorphisms, can bias intracellular signaling toward distinct pathways. Chronic receptor activation induces transcriptional and post-transcriptional reprogramming that can invert behavioral outcomes relative to acute stimulation. Intracellular signaling converges on core pathways, including Ca
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