Evidence map›Paper›PMID 42903629›Full record

ReviewStructural heart : the journal of the Heart Team2026

Transcatheter Mitral Valve Replacement: Clinical Challenges, Evolving Indications, and Future Directions.

Guido Ascione, Sebastian Ludwig, Augustin Coisne, Philipp von Stein, Nicolo Piazza, Firas Zahr, Vlasis Ninios, D Scott Lim, David V Daniels, Charanjit S Rihal and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Structural heart : the journal of the Heart Team, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Guido AscioneClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
Sebastian LudwigClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
Augustin CoisneClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
Philipp von SteinClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
Nicolo PiazzaDepartment of Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
Firas ZahrKnight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Vlasis NiniosCardiology Department, Interbalkan Medical Center, Thessaloniki, Greece.
D Scott LimInterventional Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.
David V DanielsInterventional Cardiology, Sutter Health California Pacific Medical Center, San Francisco, California, USA.
Charanjit S RihalDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Torsten P VahlClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.
Thomas ModineMedico-Surgical Department, Haut-Lévêque Cardiological Hospital; Bordeaux University Hospital, Pessac, France.
Juan F GranadaClinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitral regurgitation is a highly prevalent valvular heart disease and, when hemodynamically significant, is associated with adverse outcomes. Despite advances in surgical techniques and catheter-based edge-to-edge repair, a large number of patients remain untreated due to high surgical risk or anatomical limitations. Transcatheter mitral valve replacement (TMVR) has emerged as a promising therapeutic option for these patients. Over the past 15 years, the TMVR field has substantially progressed, with multiple devices advancing to human clinical evaluation. This review aims to provide an overview of the key milestones in TMVR development, patient selection pathways, and the transition from transapical to transseptal delivery. We further summarize the available clinical outcomes across different platforms and discuss remaining knowledge gaps, as well as future directions for this evolving field.

Indexed as

Mitral regurgitationTMVRTranscatheter mitral valve replacement

Identifiers

PMID42903629
PMCPMC13681998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.