ArticleFrontiers in psychiatry2026
Auditory sustained potential as a biomarker of language functioning in children with autism and its implication in clinical trials.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Most children with autism have language impairment, however, its neural mechanisms are not well understood. A potential biomarker associated with language in autism is a 40Hz Auditory Steady-State Response (ASSR) triggered by periodic click-trains which in electroencephalogram (EEG) evokes two types of responses - Methods: The present open-label pilot study evaluated the effects of the probiotic beverage supplement Bio-K+ in children with autism ( Results: First, at T0 we showed a reduction of SP amplitude in children with autism compared to controls, and this reduction was associated with lower speech/language/communication scores. Second, the amplitude of SP became significantly more negative during the probiotic supplementation period and, by T14, was no longer significantly different from the observed in TD controls. Finally, these changes in the amplitude of SP were associated with improvement in speech/language/communication scores. Conclusions: This study showed that the SP as well as its change was related specifically to speech/language/communication but not to other behavioral measures and has a potential to be used in future clinical trials.
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