ReviewhLife2025
Comparison of innate immune responses against arboviruses in mammalian hosts and mosquito vectors.
Review in hLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mosquito-borne arboviruses significantly threaten global health, affecting millions of people worldwide. The innate immune system is the primary line of defense against arboviruses in both mammalian hosts and mosquito vectors, although the innate immune responses of these organisms involve distinct mechanisms. This review compares the innate immune responses of mammals with those of mosquitoes, focusing on their shared reliance on pattern recognition receptors (PRRs), immune signaling pathways, and cellular innate immunity. While mosquitoes utilize RNA interference (RNAi) and melanization to control arboviral replication without inflammation, mammals depend on complement systems, complex interferon (IFN) responses, and cytokine production to rapidly clear arboviral infections. This review provides a comparative analysis of the innate immune responses of mammalian hosts and mosquito vectors, highlighting key differences in the strategies by which these organisms manage arboviral infections. Understanding these distinctions may inform the development of novel interventions to disrupt arboviral transmission and improve disease control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.