Evidence map›Paper›PMID 42903472›Full record

ArticlehLife2026

hMPV M2-2 protein modulates host mRNA alternative splicing to favor virus replication.

Jiayin Guo, Yiman Huang, Pengtao Jiao, Dongqi Xie, Gang Pang, Jiaxu Ying, Qianru Yang, Ying Wu, Siqi Wang, Xiaojuan Jia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in hLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiayin GuoShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Yiman HuangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Pengtao JiaoInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Dongqi XieDepartment of Cell Biology, University of Texas Southwestern Medical Center, Texas, USA.
Gang PangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Jiaxu YingShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Qianru YangSchool of Life Sciences, Department of Biotechnology, Fudan University, Shanghai, China.
Ying WuKey Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Hubei, China.
Siqi WangUniversity of Chinese Academy of Sciences, Beijing, China.
Xiaojuan JiaCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Miaowei MaoShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Lishu ZhengNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Ke ZhangShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human metapneumovirus (hMPV) is a widespread and prevalent respiratory pathogen, yet the mechanisms by which hMPV modulates host gene expression to facilitate replication remain incompletely characterized. Here, we systematically profiled hMPV-host protein-protein interactions by affinity purification-mass spectrometry and assessed their impact on host messenger RNA (mRNA) splicing using RNA sequencing, complemented by genetic perturbation, protein interaction assays, and fluorescence microscopy-based subcellular localization and colocalization analyses. Among the viral proteins analyzed, the regulatory protein M2-2 was found to directly interact with multiple splicing factors. Transcriptomic analysis revealed that M2-2 triggers extensive changes in alternative splicing across host genes, notably affecting genes encoding serine-threonine kinase receptor-associated protein (

Indexed as

human metapneumovirus (hMPV)M2-2mRNA splicingSTRAPTANC2

Identifiers

PMID42903472
PMCPMC13681504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.