ReviewhLife2026
Challenges posed by fungi to host immunity: Mechanisms of immune evasion.
Review in hLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive fungal infections pose a growing global public health threat with high morbidity and mortality. Rising antifungal resistance and treatment failure are largely driven by fungal immune evasion, yet systematic integration of multi-layered immune evasion mechanisms and their translational therapeutic implications remains insufficient. This review dissects the core mechanisms of fungal immune evasion, defines key nodes of host-fungi interplay, and explores emerging targeted therapeutic strategies. Fungal pathogens deploy multifaceted strategies to evade immune surveillance, including surface polysaccharide antigenic variation, β-glucan masking through structural adaptation to escape pattern recognition receptor (PRR) detection, secretion of immune-suppressive immunomodulatory molecules, complement system interference, and biofilm formation resistant to immune clearance. Moreover, fungi hijack host negative immune regulatory pathways
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.