ReviewhLife2023
SARS-CoV-2: Possible role in children with acute hepatitis of unknown origin.
Review in hLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The UK raised an alert with the World Health Organization (WHO) in April 2022 concerning a significant surge in the number of children diagnosed with acute hepatitis of unknown origin (AHUO). Despite an ongoing investigation attributing its etiology to adenovirus infection, the absence of adenovirus inclusions in liver biopsies and the remarkably low viral load raised doubts. Concurrently, reports of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in children coincided with the surge in acute hepatitis cases, prompting the need for a thorough examination of the potential connection between current or past SARS-CoV-2 infections and pediatric hepatitis epidemics. Epidemiological data suggests that acute hepatitis is a notable manifestation of the multiple-system inflammatory syndrome in children following the global SARS-CoV-2 pandemic. However, the precise role of the SARS-CoV-2 virus in liver injury etiology remains uncertain. To shed light on the potential association between SARS-CoV-2 and AHUO in children, we conducted a systematic review of epidemiological links, potential pathogenesis, and recent research findings, aiming to raise awareness and vigilance among clinicians. Convincing and definitive evidence will be essential in the future to confirm the direct impact of SARS-CoV-2 infection on children with AHUO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.