ArticleJournal of parasitology research2026
In Silico Design and Immunogenicity Evaluation of a Multiepitope Vaccine Candidate Against
Article in Journal of parasitology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cutaneous leishmaniasis caused by Methods: In this study, a MEV candidate was designed using conserved cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and linear B-cell epitopes derived from immunodominant Results: Computational analysis demonstrated stable interaction between the vaccine candidate and the TLR4 receptor. MD simulations confirmed the formation of a stable and compact vaccine-TLR4 complex, supported by RMSD, Rg, and PCA analyses, indicating reduced conformational fluctuations and enhanced receptor stabilization compared with the unbound state. Immunological analysis revealed a strong Th1-skewed immune response characterized by significant upregulation of IFN- Conclusion: Overall, the MEV induced coordinated cellular immune responses together with antigen-specific antibody recognition. The observed cytokine gene expression profile and antibody reactivity indicate a robust immunogenic response and support the recombinant construct as a promising candidate for further preclinical evaluation against cutaneous leishmaniasis. Additional studies assessing protective efficacy, parasite burden, and long-term immune durability are warranted.
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