Evidence map›Paper›PMID 42903442›Full record

ArticleEnvironment & health (Washington, D.C.)2026

ABCC1 Deficiency Mediates Susceptibility to Cd-Induced Hearing Loss via the NOX2/ROS Axis.

Shuai Zhang, Yongjia Chen, Yijiang Bai, Bo Pang, Mengzhu Jiang, Zequn Nie, Huping Huang, Lu Wang, Jie Ling, Tianhan Kai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuai ZhangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yongjia ChenDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yijiang BaiDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Bo PangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Mengzhu JiangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Zequn NieDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Huping HuangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Lu WangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Jie LingMedical Functional Experiment Center, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, China.
Tianhan KaiXiangya School of Public Health, Central South University, Changsha, Hunan 410013, China.ORCID https://orcid.org/0000-0001-5667-1426
Lingyun MeiDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID https://orcid.org/0000-0003-3034-3322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cadmium (Cd), a prevalent environmental contaminant, is associated with auditory dysfunction. The cochlear blood-labyrinth barrier (BLB) protects the inner ear from toxic substances, a process in which the ATP-binding cassette subfamily C member 1 protein, ABCC1, plays a critical role in expelling toxins from its cells. To understand the specific contribution of ABCC1 to Cd-induced hearing damage, we employed both an in vivo model (ABCC1 knockout mice,

Indexed as

ABCC1blood–labyrinth barrierCdNOX2oxidative stress

Identifiers

PMID42903442
PMCPMC13681441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.