Evidence map›Paper›PMID 42903404›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Bisphenol M Impairs Ovarian Function through Disrupting Estrogen Synthesis in Female Mice: A Comparative Study with Bisphenol A.

Shuang Luo, Fan Wu, Yuzhen Sun, Zhunjie Li, Jing Wang, Mengxi Cao, Shaochen Pang, Ling Wang, Huiming Cao, Jianan Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuang LuoHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Fan WuHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Yuzhen SunHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Zhunjie LiHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Jing WangHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Mengxi CaoHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.ORCID https://orcid.org/0009-0007-4401-9298
Shaochen PangHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Ling WangHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.
Huiming CaoHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.ORCID https://orcid.org/0000-0002-6010-8895
Jianan LiDepartment of Biotechnology, Life Science College, Jianghan University, Wuhan 430056, China.
Yong LiangHubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances, School of Environment and Health, Jianghan University, Wuhan 430056, China.ORCID https://orcid.org/0000-0003-2212-6694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisphenol M (BPM) has been increasingly used as a substitute for bisphenol A (BPA), yet its reproductive toxicity remains poorly characterized. Unlike BPA, which is well characterized as a weak estrogen receptor (ER) agonist, BPM has been identified as an ER antagonist. In this study, we systematically compared the effects of BPM and BPA on the reproductive neuroendocrine system of female mice during puberty. Five-week-old female ICR mice were exposed to BPM and BPA at doses of 1 μg/kg bw/day, 50 μg/kg bw/day, and 1 mg/kg bw/day for 14 days. Both chemicals induced comparable adverse reproductive outcomes at 50 μg/kg bw/day and 1 mg/kg bw/day, including reduced uterine weight, disrupted estrous cyclicity, depletion of primordial follicles, and increased follicle atresia. However, BPM and BPA had divergent effects on molecular and hormonal end points. BPM exposure significantly elevated ovarian

Indexed as

bisphenol Abisphenol Mestrogen receptor antagonismfemale reproductive toxicityHPG axissteroidogenesis

Identifiers

PMID42903404
PMCPMC13681431

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.