Evidence map›Paper›PMID 42903402›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Preconception Folic Acid Supplementation Associated with Attenuated Effects of Air Pollution on Birthweight Outcomes.

Yihui Ge, Yi Zhang, Jiawen Liao, Yan Lin, Zhenchun Yang, Kiros Berhane, Zhipeng Bai, Bin Han, Jia Xu, Frank Gilliland and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yihui GeNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.
Yi ZhangDepartment of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center & Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
Jiawen LiaoDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.ORCID https://orcid.org/0000-0001-8246-0542
Yan LinNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0003-4384-8354
Zhenchun YangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.ORCID https://orcid.org/0000-0002-1778-728X
Kiros BerhaneDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York 10032, United States.
Zhipeng BaiState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.ORCID https://orcid.org/0000-0002-1816-2353
Bin HanState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.ORCID https://orcid.org/0000-0002-0499-1767
Jia XuState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.ORCID https://orcid.org/0000-0003-4243-079X
Frank GillilandDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, United States.
Weili YanDepartment of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center & Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
Guoying HuangDepartment of Clinical Epidemiology & Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center & Shanghai Key Laboratory of Birth Defects, Shanghai 201102, China.
Junfeng Jim ZhangNicholas School of the Environment, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0003-3759-6672

Funding

Impact of preconception and onward exposure to air pollution on growth trajectories of infants and children (R01)R01ES029945 · NIEHS · DUKE UNIVERSITY · PI GILLILAND, FRANK D., ZHANG, JUNFENG · 2019 to 2022
$2.0M
NIEHS NIH HHS R01 ES029945
6 · The paper itself

Abstract

Gestational exposure to ambient air pollution has been linked to adverse birth outcomes. Folic acid (FA) supplementation supports fetal development, but the optimal timing for protective effects remains uncertain. This study aims to determine whether maternal FA supplementation prior to conception modifies the association between gestational air pollution exposure and birthweight-related outcomes in a population where most women also took FA during pregnancy. We analyzed data from 10,579 mother-child pairs from a preconception cohort in Shanghai, China. Ambient concentrations of PM

Indexed as

air pollutionbirthweightfolic acidlow birthweightPM2.5small-for-gestational-age

Identifiers

PMID42903402
PMCPMC13681435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.