Evidence map›Paper›PMID 42903333›Full record

ArticleFrontiers in aging neuroscience2026

Association of statin use with reduced risk of Alzheimer's disease: findings in UK Biobank.

Hui Yang, Can Zhu, Jialu He, Yan Wei, Dongmei Li, Xuan Luo, Ying Wang

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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui YangDepartment of Clinical Research Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.
Can ZhuDepartment of Clinical Research Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.
Jialu HeSchool of Public Health Management, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yan WeiDepartment of Clinical Research Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.
Dongmei LiSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xuan LuoSchool of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Ying WangDepartment of Clinical Research Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies on the association between statin use and the risk of Alzheimer's disease (AD) have yielded inconsistent results. This study, based on the large-scale UK Biobank cohort, evaluates the relationship between statin use and the risk of new-onset AD, survival in patients with AD, and cognitive function. Methods: This study included 502,401 participants with a median follow-up of 9.24 years. The association between statin use and the risk of AD was analyzed using Cox proportional hazards models, logistic regression, and propensity score matching. The robustness of the results was assessed through internal validation using training and validation groups, as well as subgroup analyses. Results: A total of 975 new cases of AD were recorded. Multivariate Cox regression analysis showed that statin use was associated with a reduced risk of AD (HR = 0.72, 95% CI: 0.52-0.98; Conclusion: Statin use was associated with a modestly lower risk of AD and slower cognitive decline. These findings highlight the importance of enhanced clinical awareness in identifying AD patients and those at risk of adverse outcomes.

Indexed as

Alzheimer’s diseasecognitive functiondementiastatinsUK Biobank

Identifiers

PMID42903333
PMCPMC13680480

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.