Evidence map›Paper›PMID 42903323›Full record

ArticleFrontiers in immunology2026

Genetic susceptibility and clinical validation of ICAM-5 in immune-mediated non-infectious uveitis.

Zihao Zhuang, Pengcheng Hu, Xuanming Hong, Tianfeng Lin, Yang Yu, Xinyu Jia, Xuemei Su, Binling Su, Wenjian Shi, Jianmin Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zihao Zhuang *Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Pengcheng Hu *Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Xuanming Hong *Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Tianfeng LinDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Yang YuDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Xinyu JiaDepartment of Plastic Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Xuemei SuDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Binling SuDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Wenjian ShiDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Jianmin HuDepartment of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate genetically supported molecular factors associated with uveitis and to evaluate the clinical, transcriptomic, and retinal relevance of intercellular adhesion molecule 5 (ICAM-5) across major immune-mediated non-infectious uveitis subtypes. Methods: Two-sample Mendelian randomization (MR) was conducted using eQTLGen eQTL data and two independent pQTL resources (Icelandic SomaScan and FinnGen R10), with uveitis GWAS summary statistics as the outcome. Results: Genetically predicted higher Conclusion: Multi-omics MR, clinical protein quantification, transcriptomic analysis, and retinal single-cell profiling provide convergent evidence linking ICAM-5 to immune-mediated non-infectious uveitis. These findings support ICAM-5 as a genetically supported candidate mediator and circulating biomarker.

Indexed as

Cell Adhesion MoleculesGenetic Predisposition to DiseaseUveitisAdultFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociUveomeningoencephalitic SyndromeCell Adhesion Moleculescirculating biomarkerICAM-5inflammationMendelian randomizationmulti-omicsnoninfectious uveitis

Identifiers

PMID42903323
PMCPMC13680458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.