Evidence map›Paper›PMID 42903266›Full record

ArticleBioinorganic chemistry and applications2026

Reevaluating Gold(I) Thiophilicity in Reduced Dielectric Environments: IRMPD Spectroscopy and Theoretical Investigation of Auranofin-Glutathione Complexes.

Roberto Paciotti, Susanna Grasso, Cecilia Coletti, Nazzareno Re, Giel Berden, Jos Oomens, Charles Desfrançois, Simonetta Fornarini, Davide Corinti, Maria Elisa Crestoni

Abstract read
In one paragraph

Article in Bioinorganic chemistry and applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Roberto PaciottiDipartimento di Farmacia Università G. D'Annunzio Chieti-Pescara Via dei Vestini 31 Chieti I-66100 Italy.ORCID https://orcid.org/0000-0001-5325-9452
Susanna GrassoDipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma, I-00185 Roma Italy.ORCID https://orcid.org/0009-0003-9707-4742
Cecilia ColettiDipartimento di Farmacia Università G. D'Annunzio Chieti-Pescara Via dei Vestini 31 Chieti I-66100 Italy.ORCID https://orcid.org/0000-0002-3609-290X
Nazzareno ReDipartimento di Farmacia Università G. D'Annunzio Chieti-Pescara Via dei Vestini 31 Chieti I-66100 Italy.ORCID https://orcid.org/0000-0002-0957-4049
Giel BerdenHFML-FELIX Toernooiveld 7 6525ED Nijmegen the Netherlands.ORCID https://orcid.org/0000-0003-1500-922X
Jos OomensHFML-FELIX Toernooiveld 7 6525ED Nijmegen the Netherlands.ORCID https://orcid.org/0000-0002-2717-1278
Charles DesfrançoisLaboratoire de Physique des Lasers CNRS Université Sorbonne Paris Nord 93430 Villetaneuse France cnrs.fr.ORCID https://orcid.org/0000-0003-2512-4387
Simonetta FornariniDipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma, I-00185 Roma Italy.ORCID https://orcid.org/0000-0002-6312-5738
Davide CorintiDipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma, I-00185 Roma Italy.ORCID https://orcid.org/0000-0001-8064-3492
Maria Elisa CrestoniDipartimento di Chimica e Tecnologie del Farmaco Sapienza Università di Roma, I-00185 Roma Italy.ORCID https://orcid.org/0000-0002-0991-5034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coordination of gold(I) to glutathione (GSH) is a fundamental process in the medicinal chemistry of auranofin and related therapeutics. Utilizing infrared multiple-photon dissociation (IRMPD) spectroscopy, electron-activated dissociation (EAD), and quantum-chemical calculations, we characterize the gas-phase structure of the complex [(Et

Indexed as

auranofinDFTEADgold(I) complexesGSHIR ion spectroscopy

Identifiers

PMID42903266
PMCPMC13680860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.