ArticleFrontiers in computational neuroscience2026
Approximate matrix exponential: a fast and accurate solver for Markov kinetic models of ion channels.
Article in Frontiers in computational neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A new method is presented for simulating Markov kinetic models of ion channels, which are biologically realistic but difficult to simulate. Computing the analytic solution is prohibitively expensive, necessitating the use of numerical methods. The new method creates a piecewise polynomial approximation of the propagator matrix, which is the analytic solution operator. The new method is an order of magnitude faster and more accurate than previous numerical methods, but it is limited to models with one or two input variables and its time complexity scales quadratically with the number of model states. The accompanying program,
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